Even though our turbos are the same, my car has a very different purpose and performance from Shakers. Right now I am running 8 lbs of boost as compared to Tom's 20 plus. That makes for a very different feeling car. The few times I have pushed mine to over 12 lbs she begins to push you in the back pretty hard. But that will have to wait as there are other concerns, such as lack of Sure Grip rear that need working on first. Even at 8 lbs of boost the rear wheel spins all the way through 1st gear. Tom's car is much, much faster than mine. But mine is still fun to drive, and has potential to tap.
However, to address a couple of your concerns:
1. The GN turbo spools up very easily and with no discernible lag. It is a none issue on my car. With a stock cam it pulls strong right to 5K RPM.
2.You are right, there is not much room under there for the Turbo and associated plumbing, especially if you are going to run an intercooler. I put mine out front behind the bumper, and cut a hole in the bumper to feed it air. The return line is under the fender and ends up being quite tight to the passenger tire, although it does clear.
3. Any turbo the Buick guys are discussing for their cars is likely a good candidate for your slant. You don't have to stick with the OEM unit. Just use their discussions of models, and sizes as a guide for your slant. I know nothing of the technicalities of this, but simply enjoyed the fact that there is a large group of guys out there who do know, and are happy to share their knowledge with you, just as they do on this forum.
4. I am intrigued by the idea of a rear mounted turbo. You got lots of room back there, and the exhaust runs all the way back. And, it is much cooler back there, with lots of air to cool it off. My intercooler piping runs about 10 feet total from the output of the turbo to the TB. Piping from the rear if properly routed and planned might be the same or less. I would like to point out that when you first start this project, it will seem like you have lots of room, and the first components are easy to fit. It is the later ones that get difficult.
5. I put my battery in the trunk. I am happy with that. The air cleaner, which is out of a Cadilac North Star V-8 sits in a well I built where the battery used to sit. I built the well to move the air cleaner box out of the way of the exit pipe from the turbo, and to allow it to pick up air from out side the engine bay.
6. Turbos create a lot of heat. If you put yours under the hood, plan some kind of vents to release the heat. I put vents in the hood, and fenders, plus put the largest fan I could get in between the radiator and engine. It works well now.
There are lots of concerns that will need to be addressed beyond what turbo you are going to use. That is the easiest part of the project really. Good luck. It is feasible, and a fun project if you are patient, and work things out as you go. I had several glitches that it took me quite some time to work out, but things are finally functioning pretty well.
Sam